180
22
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T12123 | mTOR inhibitor-3 | mTOR | |
T5338 | mTOR inhibitor-1 | mTOR , Autophagy | |
C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation. | |||
T67702 | mTOR inhibitor 9d | PI3K , mTOR | |
mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia, skin cancer, breast cancer, lung cancer and colon cancer. | |||
T67706 | mTOR inhibitor 9c | PI3K , mTOR | |
mTOR inhibitor 9c is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively. | |||
T67703 | mTOR inhibitor 9b | mTOR | |
mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTOR inhibitor 9b possesses anticancer activity and can be used to ... | |||
T67705 | mTOR inhibitor 9a | ||
mTOR inhibitor 9a inhibited the growth of human LNCap cells with an ic50 of 80 nm. 1-methyl-3 -{4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl}urea may have antitumor activity. | |||
T12459 | PI3K/mTOR Inhibitor-2 | PI3K , mTOR | |
T36316 | mTOR inhibitor-8 | mTOR-IN-8 | mTOR , Autophagy |
mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer. | |||
T67704 | mTOR inhibitor 9e | PI3K , mTOR | |
mTOR inhibitor 9e is a selective mTOR inhibitor with IC50 of 0.68nM and 1359nM for mTOR and PI3Kα, respectively. | |||
T67701 | mTOR inhibitor 9f | PI3K , mTOR | |
mTOR inhibitor 9f is a selective mTOR inhibitor with IC50 of 1.25nM and 82nM for mTOR and PI3Kα, respectively. | |||
T9310 | mTOR inhibitor 13 | PI3K , mTOR | |
mTOR inhibitor 13 is a selective mTOR inhibitor with IC50 of 0.29nM and 119nM for mTOR and PI3Kα, respectively. | |||
T12124 | mTOR inhibitor-2 | mTOR | |
mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM). | |||
T9315 | mTOR kinase Inhibitor 2 | Others | |
2H-Imidazo[4,5-b]pyrazin-2-one, 1,3-dihydro-6-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-[(tetrahydro-2H-pyran-4-yl)methyl]- is a potent mTOR inhibitor with IC50 of 0.176 μM and >30 μM for mTOR and PI3Kα, respectively. | |||
T9311 | mTOR kinase Inhibitor 1 | Others | |
can be used in research in the fields of chemistry and life sciences. | |||
T12460 | PI3K/mTOR Inhibitor-1 | PI3K | |
PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM) | |||
T11544 | HDACs/mTOR Inhibitor 1 | HDAC | |
HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1.2 nM, and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα). | |||
T9309 | mTOR inhibitor 11 | ||
mTOR inhibitor 11 is a useful organic compound for research related to life sciences. The catalog number is T9309 and the CAS number is 1195785-35-3. | |||
T79211 | mTOR inhibitor-11 | mTOR | |
mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6. It also exhibits inhibitory activity against pCHK1 and PDE4D with IC50 values of 17.2 μM and 17.0 μM,... | |||
T81744 | mTOR inhibitor-14 | mTOR | |
mTOR Inhibitor-14 (compound 14c) is a potent inhibitor of mTOR with minimal inhibition of CYP2C8 and has demonstrated the capability to inhibit tumor growth [1]. | |||
T79212 | mTOR inhibitor-12 | mTOR | |
mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to central nervous system (CNS) diseases [1]. | |||
T35343 | MTI-31 | MTI-31,LXI-15029 | mTOR |
MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding a... | |||
T63770 | PI3K/mTOR Inhibitor-4 | ||
PI3K/mTOR Inhibitor-4 is an orally active pan-I PI3K/mTOR inhibitor. PI3K/mTOR Inhibitor-4 is an enzyme inhibitor that acts on PI3Kα (IC50: 0.63 nM), PI3Kγ (IC50: 22 nM), PI3Kδ (IC50: 9.2 nM) and mTOR (IC50: 13.85 nM). P... | |||
T72374 | PI3K/mTOR Inhibitor-12 | PI3K | |
PI3K/mTOR Inhibitor-12, a potent and selective orally active inhibitor, exhibits IC50 values of 0.06 nM for PI3Kα and 3.12 nM for mTOR, indicating significant antitumor activity with reduced liver toxicity [1]. | |||
T72380 | PI3K/mTOR Inhibitor-13 | ||
PI3K/mTOR Inhibitor-13, an orally active dual inhibitor targeting phosphoinositol 3-kinase (PI3K) and mTOR kinase, holds potential for treating sexual diseases, solid tumors, and idiopathic pulmonary fibrosis (IPF). | |||
T14033 | 3BDO | Apoptosis , mTOR , Autophagy | |
3BDO is an activator of mTOR. It can also inhibit autophagy.. | |||
T64219 | PI3K/mTOR Inhibitor-6 | ||
PI3K/mTOR Inhibitor-6 (Compound 19c) is a potent dual PI3K/mTOR inhibitor that is more stable than gedatolisib in artificial gastric fluid. 10 μM of PI3K/mTOR Inhibitor-6 significantly inhibits the PI3K/Akt/mTOR signalli... | |||
T61516 | PI3K/mTOR Inhibitor-3 | ||
PI3K/mTOR Inhibitor-3 (compound 12) is an imidazoline compound with potent dual inhibitory effects on PI3K and mTOR. This compound exhibits notable anti-cancer activity [1]. | |||
T81470 | PI3K/mTOR Inhibitor-14 | PI3K | |
PI3K/mTOR Inhibitor-14 (compound Y-2) serves as a dual inhibitor of PI3K and mTOR, exhibiting IC50 values of 171.4 nM and 10.1 nM , respectively, and demonstrates antitumor activities [1]. | |||
T64041 | PI3K/mTOR Inhibitor-7 | ||
PI3K/mTOR Inhibitor-7 is a potent dual PI3K/mTOR inhibitor. PI3K/mTOR Inhibitor-7 is 4.7-fold more potent than gedatolisib, with IC50 values of 1.4 μM and 0.3 μM, respectively. 10 μM of PI3K/mTOR Inhibitor-7 is able to s... | |||
T63470 | PI3K/mTOR Inhibitor-8 | ||
PI3K/mTOR Inhibitor-8 is a dual inhibitor of PI3K (PI3Kα IC50: 0.46 nM) and mTOR (mTOR IC50: 12 nM). PI3K/mTOR Inhibitor-8 blocks the cell cycle of HCT-116 cells in G1/S phase and induces apoptosis. apoptosis). | |||
T72408 | PI3K/mTOR Inhibitor-5 | ||
PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively. | |||
T62438 | PI3K/mTOR Inhibitor-9 | ||
PI3K/mTOR Inhibitor-9 (Compound 1) is a potent inhibitor of both mTOR and PI3K, acting on mTOR (IC50: 38 nM), PI3Kα (IC50: 6.6 nM), PI3Kγ (IC50: 6.6 nM) and PI3Kδ (IC50: 0.8 nM). | |||
T6045 | Torin 1 | DNA-PK , PI3K , mTOR , Autophagy | |
Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K. | |||
T40351 | MHY-1685 | mTOR | |
MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy. | |||
T6030 | XL388 | P450 , PI3K , mTOR | |
XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases. | |||
T12270 | NV-5138 | mTOR | |
NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects. | |||
T3514 | CZ415 | mTOR | |
CZ415 is a potent and highly selective mTOR inhibitor. | |||
T2475 | KU-0063794 | mTOR | |
KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2. | |||
T5472 | PQR620 | mTOR | |
PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2. | |||
T1859 | AZD-8055 | Apoptosis , mTOR , Autophagy | |
AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms. | |||
T7343 | PF-04979064 | PI3K , mTOR | |
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively). | |||
T7166 | GNE-493 | PI3K , mTOR | |
GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR,respectively. | |||
T6100 | Torin 2 | Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy | |
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 2... | |||
T16355 | NSC781406 | PI3K , mTOR | |
NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα). | |||
T1961 | Vistusertib | AZD2014 | Apoptosis , Akt , PI3K , S6 Kinase , mTOR , Autophagy |
Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. | |||
T6845 | GNE-317 | GNE317 | PI3K , mTOR |
GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB). | |||
T3692 | GNE-477 | GNE 477 | PI3K , mTOR |
GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor. | |||
T16567 | PQR530 | PQR-530 | PI3K , mTOR |
PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 μM. It also showing antitu... | |||
T4199 | Desmethyl-VS-5584 | PI3K , mTOR | |
Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. | |||
T1908 | MHY1485 | mTOR , Autophagy | |
MHY1485 is a mTOR activator. It inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes, leading to the accumulation of LC3II protein and enlarged autophagosomes. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TN1891 | Lupiwighteone | Apoptosis , BCL , PARP , Caspase | |
Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells. | |||
T5S0658 | Corynoxine | Autophagy | |
Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla. It is an autophagy enhancer that promotes α-synuclein clearance through the Akt/mTOR pathway. | |||
T2717 | Salidroside | Rhodioloside | Apoptosis , mTOR |
Salidroside (Rhodioloside) is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata. It is a prolyl endopeptidase Inhibitor. | |||
T2998 | Dihydromyricetin | Ampelopsin,Ampeloptin | Influenza Virus , GABA Receptor , DNA/RNA Synthesis , mTOR , Autophagy |
Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy... | |||
T5S0506 | Rotundic acid | Rutundic acid | Apoptosis , Others , p38 MAPK , Akt , mTOR |
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c... | |||
T3895 | Polyphyllin I | Apoptosis , Akt , JNK , PDK , mTOR , Autophagy | |
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha... | |||
T3O2749 | L-Leucine | (S)-Leucine,Leu | mTOR |
L-Leucine ((S)-Leucine) is one of nine essential amino acids in humans (provided by food), L-Leucine is important for protein synthesis and many metabolic functions. L-Leucine contributes to regulation of blood-sugar lev... | |||
TN4761 | Phellamurin | P-gp | |
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadmini... | |||
TN1405 | Arnicolide D | Akt , Caspase , PI3K , STAT , mTOR | |
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path... | |||
T6354 | (+)-Usnic acid | D-Usnic Acid,(+)-Usniacin | Antiviral , Antibacterial , mTOR |
(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species. | |||
T5740 | 25(R,S)-Ruscogenin | (25RS)-Ruscogenin | Others , HIF |
25(R,S)-Ruscogenin is a natual product. | |||
T2974 | Cyclovirobuxine D | CVB-D,Bebuxine,Cyclovirobuxin D | Apoptosis , Others , Akt , mTOR , Autophagy |
Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla. | |||
T1537 | Rapamycin | Sirolimus,AY 22989,NSC-2260804 | Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal |
Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy. | |||
T3981 | Acacetin | 4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin | Apoptosis , IAP , COX , Autophagy |
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models. | |||
T2P2806 | Hederacolchiside A1 | Raddeanoside R13 | Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR |
Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacol... | |||
T2851 | Daphnetin | 7,8-Dihydroxycoumarin,Daphnetol | EGFR , PKA , PKC , Parasite , Autophagy |
Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-... | |||
T2995 | Chrysophanol | 3-Methylchrysazin,Chrysophanic Acid,Turkey Rhubarb | EGFR |
Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel. | |||
TN2085 | Piperlonguminine | Anti-infection , Antibacterial , Antifungal | |
Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities.Piperl... | |||
T16165 | Myriocin | ISP-I,Thermozymocidin | HCV Protease , Antifungal |
Myriocin (Thermozymocidin), a metabolite derived from Myriococcum albomyces, is a serine-palmitoyltransferase (SPT) inhibitor with potential antitumour, anticancer, and antiparasitic activities.Myriocin inhibits tumour g... | |||
T4672 | Brevilin A | Apoptosis , Anti-infection , JAK , STAT , Autophagy | |
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si... | |||
TN4788 | Pierreione B | mTOR | |
Pierreione B is an inhibitor of mTOR signaling with strong anticancer activity. Pierreione A and Pierreione B demonstrate solid tumor selectivity with minimal cytotoxicity. | |||
T27305 | Fascaplysin chloride | NSC622398,NSC 622398,Fascaplysin,NSC-622398 | |
Fascaplysin is a cyclin D kinase 4/ cyclin D1 inhibitor (IC50 = 0.35 μM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K/AKT/mTOR signaling cascade in human ... |